Calponin Mouse anti-Human, Clone: 1A11E5, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 665401IG150UL

Catalog No. 50-173-6960

Description

This antibody raised against the specific region of human CNN1, thus it does not cross-react with CNN2 or CNN3.

Calponin, a thin filament associated protein is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34kDa and 29kDa. Expression of the 29kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and maligt breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.

Specifications

• Antigen: Calponin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: P51911
• Gene Symbols: CNN1
• Immunogen: Calponin Fusion Protein Ag21384
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: 1A11E5
• Conjugate: Unconjugated
• Gene: CNN1
• Gene Alias: Basic calponin, Calponin 1, Calponin H1, smooth muscle, CNN1, Sm Calp, SMCC
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1264
• Content And Storage: -20°C
• Form: Liquid