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Invitrogen™ Calreticulin 3 Polyclonal Antibody
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Catalog No. PIPA5114934
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100 μL
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PIPA5114934 100 μL
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Catalog No. PIPA5114934 Supplier Invitrogen™ Supplier No. PA5114934
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total CALR3.

Calreticulin 3 (CALR3) is a gene located on chromosome 19p13.11, encoding a member of the calreticulin family of calcium-binding chaperones. Unlike the more ubiquitously expressed calreticulin (CALR), CALR3 is specifically expressed in the testes and plays a crucial role in spermatogenesis. CALR3 is involved in the quality control of proteins within the endoplasmic reticulum (ER) and assists in the folding and assembly of newly synthesized glycoproteins. This protein's function is essential for the maturation of sperm cells and male fertility, as it helps ensure the proper formation and function of sperm-specific proteins. Mutations in CALR3 have been associated with familial hypertrophic cardiomyopathy, reflecting its potential involvement in cardiac muscle function through mechanisms that remain to be fully elucidated. Research continues to explore CALR3's specific roles in reproductive biology and its implications in hereditary conditions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Calreticulin 3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene Calr3
Gene Accession No. Q96L12, Q9D9Q6
Gene Alias 1700031L01Rik; 6330586I20Rik; CALR3; calreticulin 3; calreticulin-2; Calreticulin-3; calspeculin; calsperin; cancer/testis antigen 93; CMH19; CRT2; cspn; CT93; EGK_10275; testis secretory sperm-binding protein Li 226n
Gene Symbols Calr3
Host Species Rabbit
Immunogen A synthesized peptide derived from human CALR3(Accession Q96L12), corresponding to amino acid residues A325-F375.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 125972, 364529, 73316
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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