Invitrogen™ Calreticulin 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529451

Catalog No. PIPA529451

Description

Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (81%), Rat (83%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Calreticulin 3 (CALR3) is a gene located on chromosome 19p13.11, encoding a member of the calreticulin family of calcium-binding chaperones. Unlike the more ubiquitously expressed calreticulin (CALR), CALR3 is specifically expressed in the testes and plays a crucial role in spermatogenesis. CALR3 is involved in the quality control of proteins within the endoplasmic reticulum (ER) and assists in the folding and assembly of newly synthesized glycoproteins. This protein's function is essential for the maturation of sperm cells and male fertility, as it helps ensure the proper formation and function of sperm-specific proteins. Mutations in CALR3 have been associated with familial hypertrophic cardiomyopathy, reflecting its potential involvement in cardiac muscle function through mechanisms that remain to be fully elucidated. Research continues to explore CALR3's specific roles in reproductive biology and its implications in hereditary conditions.

Specifications

• Antigen: Calreticulin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Calr3
• Gene Alias: 1700031L01Rik; 6330586I20Rik; CALR3; calreticulin 3; calreticulin-2; Calreticulin-3; calspeculin; calsperin; cancer/testis antigen 93; CMH19; CRT2; cspn; CT93; EGK_10275; testis secretory sperm-binding protein Li 226n
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 125972, 73316
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q96L12, Q9D9Q6
• Gene Symbols: Calr3
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Calreticulin 3. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG