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Invitrogen™ Calsequestrin 2 Polyclonal Antibody

Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA521706
Description
Recommended positive controls: HCT116. Predicted reactivity: Mouse (95%), Rat (96%), Dog (96%), Rabbit (96%), Chicken (90%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.
Specifications
Calsequestrin 2 | |
Polyclonal | |
Unconjugated | |
Casq2 | |
AA033488; AW146219; calsequestrin; calsequestrin 2; calsequestrin 2 (cardiac muscle); calsequestrin 2, fast-twitch, cardiac muscle; calsequestrin, cardiac muscle isoform; Calsequestrin-2; cardCSQ; cardiac calsequestrin; CASQ2; cCSQ; Csq2; ESTM52; LOW QUALITY PROTEIN: calsequestrin-2; PDIB2; SR calcium binding protein | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
12373, 845 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.68 mg/mL | |
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7 | |
O09161, O14958 | |
Casq2 | |
Recombinant protein encompassing a sequence within the center region of human Calsequestrin 2. The exact sequence is proprietary. | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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