Invitrogen™ Calsequestrin 2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597540

Catalog No. PIPA597540

Description

Calsequestrin 2 Polyclonal Antibody for Western Blot, IHC (P), ELISA

Calsequestrin (CASQ) is a Ca2+-binding protein present primarily in junctional sarcoplasmic reticulum of skeletal and cardiac muscle; the cardiac form (CASQ2) is encoded by a separate gene. The primary role of CASQ2 is buffering of the sarcoplasmic reticulum Ca2+ ions, but another role for CASQ2 has emerged recently: CASQ2 regulates the open probability of ryanodine receptor 2 (RyR2). Mutations in CASQ2 cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest.

Specifications

• Antigen: Calsequestrin 2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Casq2
• Gene Alias: AA033488; AW146219; calsequestrin; calsequestrin 2; calsequestrin 2 (cardiac muscle); calsequestrin 2, fast-twitch, cardiac muscle; calsequestrin, cardiac muscle isoform; Calsequestrin-2; cardCSQ; cardiac calsequestrin; CASQ2; cCSQ; Csq2; ESTM52; LOW QUALITY PROTEIN: calsequestrin-2; PDIB2; SR calcium binding protein
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 845
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.68 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: O14958
• Gene Symbols: Casq2
• Immunogen: Recombinant Human Calsequestrin-2 protein (219-300AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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