Invitrogen™ CaMKIV Monoclonal Antibody (8C5B8)

Catalog No.	Quantity
PIMA517038	100 μg

Catalog No. PIMA517038 Supplier Invitrogen™ Supplier No. MA517038

Description

Mouse Monoclonal Antibody

MA5-17038 targets CAMK4 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples. The MA5-17038 immunogen is purified recombinant fragment of human CAMK4 (amino acids: 35-292 ) expressed in E. Coli. MA5-17038 detects CAMK4 which has a predicted molecular weight of approximately 58kDa.

CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphoryates CREB, oncoprotein 18, and SRF. It has limited tissue distribution, and has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees. In neurons, CaMKIV is thought to play an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein plays an important role in calcium signaling which could affect the transcription regulatory protein, nuclear factor of activated T-cells (NFAT). CaMKIV is encoded, along with calspermin, by the CaMKIV gene. It has been found that, in testes, CaMKIV is expressed in germ cells and found to be associated with chromatin. The association of CaMKIV with chromatin suggests a potential role in chromatin remodeling during nuclear condensation in spermatids.

Specifications

• Antigen: CaMKIV
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 8C5B8
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% sodium azide
• Gene: CAMK4
• Gene Accession No.: Q16566
• Gene Alias: A430110E23Rik; AI666733; brain Ca(2+)-calmodulin-dependent protein kinase type IV; brain Ca++-calmodulin-dependent protein kinase type IV; Ca2+/calmodulin-dependent protein kinase type IV/Gr; Calcium/calmoduli; calcium/calmodulin dependent protein kinase IV; calcium/calmodulin-dependent protein kinase IV; calcium/calmodulin-dependent protein kinase IV L homeolog; calcium/calmodulin-dependent protein kinase type IV; calcium/calmodulin-dependent protein kinase type IV catalytic chain; Calmodulin-dependent protein kinase IV; calspermin; CAM kinase- GR; CAM kinase IV; CAM kinase-GR; CAMK; CaMK IV; camk4; camk4.L; camk4-A; CAMK-GR; CAMKIV; CaMKIV/Gr; Ccdpk; D18Bwg0362e; EC 2.7.11.17; KCC4; kinase CaMK4; OTTHUMP00000222818; RATCCDPK; xCaM; XELAEV_18008011mg
• Gene Symbols: CAMK4
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human CAMK4 (amino acids: 35-292 ) expressed in E. Coli.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 814
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1