Carbenicillin Disodium Salt, MP Biomedicals™

Description

Displays antipseudomonal and antiproteal effects. Carbenicillin Disodium Salt, MP Biomedicals is a carboxypenicillin antibiotic that inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface

Carbenicillin is a semi-synthetic antibiotic that is an analog to ampicillin. It is derived from benzyl penicillin by substituting the a-carboxyl group in the benzyl side chain. It is completely ionized in the blood and is about 50% reversibly protein bound in plasma. Its tissue distribution is similar to other penicillins.

Susceptible bacteria include gram-positive and gram-negative bacteria abd pseudomonas.Though it has substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal effect.

Carbenicillin Disodium Salt is used for selection of ampr transformed cells and to study the role of penicillin-sensitive transpeptidases in cell wall biosynthesis.

Specifications

Chemical Identifiers

• CAS: 4800-94-6
• Molecular Formula: C17H16N2Na2O6S
• Molecular Weight (g/mol): 422.36
• MDL Number: MFCD00077683
• InChI Key: RTYJTGSCYUUYAL-YCAHSCEMSA-L
• Synonym: α-Carboxybenzylpenicillin
• PubChem CID: 20933
• ChEBI: CHEBI:34609
• IUPAC Name: disodium;(2S,5R,6R)-6-[(2-carboxylato-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• SMILES: [Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)C(C([O-])=O)C3=CC=CC=C3)C(=O)N2[C@H]1C([O-])=O

• Physical Form: Powder
• Potency: >650μg/mg
• Concentration: Working Concentration: 105u/L (5-50μg/mL) in cell culture; approximately 200mg/kg in vivo.
• Quantity: 250 mg
• Solubility Information: Soluble in water (50mg/mL) and alcohol
• Formula Weight: 422.4

Safety and Handling

Recommended Storage

Store at 4°C, desiccate.

WARNING: Reproductive Harm - www.P65Warnings.ca.gov