Carbonic Anhydrase IX/CA9 Antibody (66.4.C2 (PN-15)), Alexa Fluor™ 350, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP233152AF350

Catalog No. NB005702

Description

Carbonic Anhydrase IX/CA9 Monoclonal specifically detects Carbonic Anhydrase IX/CA9 in Human, Equine samples. It is validated for Immunohistochemistry-Paraffin.

Specifications

• Antigen: Carbonic Anhydrase IX/CA9
• Classification: Monoclonal
• Conjugate: Alexa Fluor 350
• Formulation: 50mM Sodium Borate with 0.05% Sodium Azide
• Gene Symbols: CA9
• Immunogen: Fresh, normal human renal cortical tissue homogenate was used to generate the Carbonic Anhydrase IX/CA9 Antibody (66.4.C2 (PN-15)).
• Quantity: 0.1 mL
• Research Discipline: Cancer, HIF Target Genes, Hypoxia, Lipid and Metabolism, Metastasis, Renal Cell Carcinoma Cell Markers
• Test Specificity: Recognizes a glycoprotein of ∼200kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowmans capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This monoclonal antibody may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.
• Content And Storage: Store at 4°C in the dark.

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Clone: 66.4.C2 (PN-15)
• Dilution: ELISA, Immunohistochemistry-Paraffin
• Gene Alias: CAIX, CA-IX, Carbonate dehydratase IX, carbonic anhydrase 9, carbonic anhydrase IX, carbonic dehydratase, EC 4.2.1.1, G250, Membrane antigen MN, MN, P54/58N, PMW1, RCC-associated antigen G250, RCC-associated protein G250, Renal cell carcinoma-associated antigen G250
• Host Species: Mouse
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Equine
• Isotype: IgG2b κ