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Invitrogen™ Carbonic Anhydrase IX Monoclonal Antibody (2D3)
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Catalog No. PIMA515737
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100 μL
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Catalog No. Quantity
PIMA515737 100 μL
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Catalog No. PIMA515737 Supplier Invitrogen™ Supplier No. MA515737
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Description

Mouse Monoclonal Antibody

MA5-15737 targets CA9 in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human samples. The MA5-15737 immunogen is purified recombinant fragment of human CA9 expressed in E. Coli. MA5-15737 detects CA9 which has a predicted molecular weight of approximately 50kDa.

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Carbonic Anhydrase IX
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2D3
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation ascites with 0.03% sodium azide
Gene CA9
Gene Accession No. Q16790
Gene Alias Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250
Gene Symbols CA9
Host Species Mouse
Immunogen Purified recombinant fragment of human CA9 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 768
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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