Invitrogen™ Carbonic Anhydrase IX Recombinant Rabbit Monoclonal Antibody (2K2W3)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538127

Catalog No. PIMA538127

Description

Positive Samples: HT-29, SW620 Immunogen sequence: HSVQLTLPPG LEMALGPGRE YRALQLHLHW GAAGRPGSEH TVEGHRFPAE IHVVHLSTAF ARVDEALGRP GGLAVLAAFL EEGPEENSAY EQLLSRLEEI A.

Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.

Specifications

• Antigen: Carbonic Anhydrase IX
• Classification: Recombinant Monoclonal
• Concentration: 0.4 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q16790
• Gene Symbols: CA9
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Carbonic Anhydrase 9 (CA9/G250) (Q16790).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Clone: 2K2W3
• Conjugate: Unconjugated
• Gene: CA9
• Gene Alias: Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 768
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

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