Invitrogen™ Carbonic Anhydrase VA/VB Monoclonal Antibody (487908)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524199

Catalog No. PIMA524199

Description

In Western blots, no cross-reactivity with recombinant human CA1, 4, or CA6-14 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. CAs are involved in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric juice. They show extensive diversity in distribution and in their subcellular localization. The human CA5A gene encodes for the CA V protein which is expressed in the mitochondrial matrix in liver tissues, but can also be detected in many other tissues. In ureagenesis, the CA V protein may be involved in providing bicarbonate to carbamoyl phosphate synthetase. CA5B belongs a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. This protein is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. The protein has a wider tissue distribution than CA VA, which is restricted to the liver.

Specifications

• Antigen: Carbonic Anhydrase VA/VB
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P35218, Q9Y2D0
• Gene Symbols: CA5A, CA5B
• Immunogen: E. coli-derived recombinant human Carbonic Anhydrase VA/VB (CA5A/5B) Ala40-Ser305.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 487908
• Conjugate: Unconjugated
• Gene: CA5A
• Gene Alias: CA5; CA5A; CA5AD; CA5B; Carbonate dehydratase VA; carbonate dehydratase VB; carbonic anhydrase 5A; carbonic anhydrase 5A, mitochondrial; carbonic anhydrase 5B; carbonic anhydrase 5B, mitochondrial; carbonic anhydrase V, mitochondrial; Carbonic anhydrase VA; carbonic anhydrase VA, mitochondrial; Carbonic anhydrase VB; carbonic anhydrase VB, mitochondrial; carbonic dehydratase; CAV; CAVA; CA-VA; CA-VB; GS1-21A4.1
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 11238, 763
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized