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Invitrogen™ Carbonic Anhydrase VA/VB Monoclonal Antibody (487908)
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Catalog No. PIMA524199
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100 μg
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PIMA524199 100 μg
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Catalog No. PIMA524199 Supplier Invitrogen™ Supplier No. MA524199
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Description

Mouse Monoclonal Antibody

In Western blots, no cross-reactivity with recombinant human CA1, 4, or CA6-14 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Carbonic anhydrases (CAs) are members of a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. CAs are involved in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric juice. They show extensive diversity in distribution and in their subcellular localization. The human CA5A gene encodes for the CA V protein which is expressed in the mitochondrial matrix in liver tissues, but can also be detected in many other tissues. In ureagenesis, the CA V protein may be involved in providing bicarbonate to carbamoyl phosphate synthetase. CA5B belongs a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. This protein is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. The protein has a wider tissue distribution than CA VA, which is restricted to the liver.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Carbonic Anhydrase VA/VB
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 487908
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene CA5A
Gene Accession No. P35218, Q9Y2D0
Gene Alias CA5; CA5A; CA5AD; CA5B; Carbonate dehydratase VA; carbonate dehydratase VB; carbonic anhydrase 5A; carbonic anhydrase 5A, mitochondrial; carbonic anhydrase 5B; carbonic anhydrase 5B, mitochondrial; carbonic anhydrase V, mitochondrial; Carbonic anhydrase VA; carbonic anhydrase VA, mitochondrial; Carbonic anhydrase VB; carbonic anhydrase VB, mitochondrial; carbonic dehydratase; CAV; CAVA; CA-VA; CA-VB; GS1-21A4.1
Gene Symbols CA5A, CA5B
Host Species Mouse
Immunogen E. coli-derived recombinant human Carbonic Anhydrase VA/VB (CA5A/5B) Ala40-Ser305.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11238, 763
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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