Invitrogen™ Carbonic Anhydrase XIII Polyclonal Antibody

Catalog No.	Quantity
PIPA547269	100 μg

Catalog No. PIPA547269 Supplier Invitrogen™ Supplier No. PA547269

Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, approximately 15% cross-reactivity with recombinant human (rh) CA1, rhCA2, and rhCA3 is observed and 5% cross-reactivity with rhCA4, rhCA8, rhCA9, rhCA10, rhCA12, and rhCA14 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Carbonic anhydrase XII (CA XII), encoded by the CA12 gene, is one of the enzyme isoforms in the carbonic anhydrase family that catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons. CA XII is a transmembrane protein expressed in various tissues, including the kidneys, intestines, and lungs, playing crucial roles in maintaining acid-base balance, pH regulation, and electrolyte transport. Its activity is significant in organs where fluid secretion and absorption are essential processes, impacting functions such as respiration and renal bicarbonate reabsorption. CA XII is involved in physiological processes like cell proliferation and differentiation by modulating the extracellular and intracellular pH, influencing tumor microenvironment dynamics. Aberrant expression of CA XII has been noted in several cancers, including breast and colorectal cancers, where it supports tumor growth and metastasis by maintaining the acid-base homeostasis conducive to cancer cell survival. Due to its surface expression and role in maintaining pH balance, CA XII is a target of interest for therapeutic interventions aiming to disrupt tumor progression and enhance the efficacy of cancer treatments.

Specifications

• Antigen: Carbonic Anhydrase XIII
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: Ca13
• Gene Accession No.: Q8N1Q1
• Gene Alias: 2310075C21Rik; Ca13; Car13; Carbonate dehydratase XIII; carbonic anhydrase 13; Carbonic anhydrase XIII; CAXIII; CA-XIII; RGD1560453
• Gene Symbols: Ca13
• Host Species: Goat
• Immunogen: E. coli-derived recombinant human Carbonic Anhydrase XIII/CA13 Ser2-His262.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 377677
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG