Invitrogen™ Carboxypeptidase A1 Monoclonal Antibody (CL6607)

Catalog No.	Quantity
PIMA531440	100 μL

Catalog No. PIMA531440 Supplier Invitrogen™ Supplier No. MA531440

Description

Mouse Monoclonal Antibody

Immunogen sequence: DFVGHQVLRI SVADEAQVQK VKELEDLEHL QLDFWRGPAH PGSPIDVRVP FPSIQAVKIF LESHGISYET Highest antigen sequence indentity to the following orthologs: Rat - 84%, Mouse - 77%.

CPA1, also known as CPA, is a 419 amino acid secreted monomeric protein that is highly expressed in pancreatic tissue. Functioning as a pancreatic exopeptidase, CPA1 uses zinc as a cofactor to catalyze the release of C-terminal amino acids from a variety of proteins, thereby playing a key role in protein digestion and degradation. Via its catalytic activity, CPA1 is also thought to be involved in zymogen (proenzyme) inhibition, probably functioning to block enzyme activation pathways. Abnormal levels of CPA1 are associated with pancreatic cancer, suggesting a possible role in either tumor progression or tumor suppression events.

Specifications

• Antigen: Carboxypeptidase A1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: CL6607
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Cpa1
• Gene Accession No.: P15085
• Gene Alias: 0910001L12Rik; carboxypeptidase A; carboxypeptidase A1; carboxypeptidase A1 (pancreatic); carboxypeptidase A1, pancreatic; CPA; Cpa1; pancreatic carboxypeptidase A; pancreatic procarboxypeptidase A
• Gene Symbols: Cpa1
• Host Species: Mouse
• Immunogen: Recombinant protein fragment of Human CPA1 (Product #RP-92630)
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1357
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b