Invitrogen™ Carboxypeptidase A1 Polyclonal Antibody

Catalog No.	Quantity
PIPA582776	100 μL

Catalog No. PIPA582776 Supplier Invitrogen™ Supplier No. PA582776

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MIEDVQSLLD EEQEQMFAFR SRARSTDTFN YATYHTLEEI YDFLDLLVAE NPHLVSKIQI GNTYEGRPIY VLKF Highest antigen sequence indentity to the following orthologs: Rat - 80%, Mouse - 78%.

CPA1, also known as CPA, is a 419 amino acid secreted monomeric protein that is highly expressed in pancreatic tissue. Functioning as a pancreatic exopeptidase, CPA1 uses zinc as a cofactor to catalyze the release of C-terminal amino acids from a variety of proteins, thereby playing a key role in protein digestion and degradation. Via its catalytic activity, CPA1 is also thought to be involved in zymogen (proenzyme) inhibition, probably functioning to block enzyme activation pathways. Abnormal levels of CPA1 are associated with pancreatic cancer, suggesting a possible role in either tumor progression or tumor suppression events.

Specifications

• Antigen: Carboxypeptidase A1
• Applications: Immunohistochemistry (Paraffin)
• Classification: Polyclonal
• Concentration: 0.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: Cpa1
• Gene Accession No.: P15085
• Gene Alias: 0910001L12Rik; carboxypeptidase A; carboxypeptidase A1; carboxypeptidase A1 (pancreatic); carboxypeptidase A1, pancreatic; CPA; Cpa1; pancreatic carboxypeptidase A; pancreatic procarboxypeptidase A
• Gene Symbols: Cpa1
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human CPA1. Recombinant protein control fragment (Product #RP-92631).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1357
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG