Invitrogen™ Carboxypeptidase B2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110680

Catalog No. PIPA5110680

Description

Immunogen sequence: QVLAALPRTS RQVQVLQNLT TTYEIVLWQP VTADLIVKKK QVHFFVNASD VDNVKAHLNV SGIPCSVLLA DVEDLIQQQI SNDTVSPRAS ASYYEQYHSL NEIYSWIEFI TERHPDMLTK IHIGSSFEKY PLYVLKVSGK EQAA Highest antigen sequence indentity to the following orthologs: Mouse - 84%, Rat - 81%.

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for its gene and its promoter region.

Specifications

• Antigen: Carboxypeptidase B2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CPB2
• Gene Alias: 1110032P04Rik; 4930405E17Rik; AI255929; carboxypeptidase B2; carboxypeptidase B2 (plasma); carboxypeptidase B2 (plasma, carboxypeptidase U); carboxypeptidase B-like protein; carboxypeptidase R; Carboxypeptidase U; Cpb2; CPR; CPU; pCPB; Plasma carboxypeptidase B; Tafi; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1361
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96IY4
• Gene Symbols: CPB2
• Immunogen: Recombinant Protein corresonding to Human Carboxypeptidase B2. Recombinant protein control fragment (Product #RP-102322).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG