Invitrogen™ CARD10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103188

Catalog No. PIPA5103188

Description

Antibody detects endogenous levels of total CARD10.

CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-Kappa-B activation. When expressed in cells, this protein binds to BCL10 and activates NF-Kappa-B Recent experiments have shown that CARMA3 is required for EGF-induced NF-Kappa-B activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.

Specifications

• Antigen: CARD10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CARD10
• Gene Alias: AI449026; Bcl10 binding protein and activator of NFKB; bcl10-interacting MAGUK protein 1; Bimp1; Card10; CARD-containing MAGUK 3 protein; CARD-containing MAGUK protein 3; Carma 3; Carma3; caspase recruitment domain family member 10; caspase recruitment domain family, member 10; caspase recruitment domain-containing protein 10
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 105844, 29775
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P58660, Q9BWT7
• Gene Symbols: CARD10
• Immunogen: A synthesized peptide derived from human CARD10(Accession Q9BWT7), corresponding to amino acid residues T68-Q118.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG