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Invitrogen™ CARD14 Polyclonal Antibody
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Catalog No. PA550370
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100 μL
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PA550370 100 μL
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Catalog No. PA550370 Supplier Invitrogen™ Supplier No. PA550370
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total CARD14 / CARMA2 protein.

Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 14 is a 1,004 amino acid protein consisting of an N-terminal CARD domain, a central coiled-coil domain and a C-terminal tripartite domain comprised of a PDZ domain, an Src homology 3 domain and a GUK domain with homology to guanylate kinase. CARD 14 is expressed in the placenta where it positively regulates apoptosis. CARD 14 also controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex. Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CARD14
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene CARD14
Gene Accession No. Q9BXL6
Gene Alias Bcl10-interacting MAGUK protein 2; BIMP2; Card14; CARD-containing MAGUK protein 2; Carma 2; CARMA2; caspase recruitment domain family member 14; caspase recruitment domain family, member 14; caspase recruitment domain-containing protein 14; PRP; PSORS2; PSS1
Gene Symbols CARD14
Host Species Rabbit
Immunogen Fusion protein corresponding to a region derived from internal residues of human caspase recruitment domain family, member 14.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79092
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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