Invitrogen™ CARD14 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120462

Catalog No. PIPA5120462

Description

Positive test controls include: HT-29, HeLa. The target is usually found in the following locations: Cytoplasm, Cytoplasm. Immunogen sequence: SLSLHYSNAL QEKELAASRC RSLQEELYLL KQELQRANMV SSCELELQEQ SLRTASDQES GDEELNRLKE ENEKLRSLTF SLAEKDILEQ SLDEARGSRQ ELVERIHSLR ERAVAAERQR EQYWEEKEQT LLQFQKSKMA CQLYREKVNA LQAQVCELQK ERDQAYSARD SAQREISQSL VEKDSLRRQV FELTDQVCEL RTQLRQLQAE PPGVLKQEAR TREPCPREKQ RLVRMHAICP RDDSDCSLVS STESQLLSDL SATSSRELVD SFRSSSPAPP SQQSLYKRVA EDFGEEPWSF S.

Membrane-associated guanylate kinase (MAGUK) family members localize to the plasma membrane and function as molecular scaffolds for the assembly of multi-protein complexes. The MAGUK family includes several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product, such as postsynaptic proteins, GKAPs, the tight junction associated proteins (ZO-1-3) and the caspase-associated recruitment domain (CARD) proteins: CARD 6, CARD 8-12 and CARD 14. CARD 14 is a 1,004 amino acid protein consisting of an N-terminal CARD domain, a central coiled-coil domain and a C-terminal tripartite domain comprised of a PDZ domain, an Src homology 3 domain and a GUK domain with homology to guanylate kinase. CARD 14 is expressed in the placenta where it positively regulates apoptosis. CARD 14 also controls NF-kappaB activation by phosphorylating BCL10, a signaling protein that activates NF-kappaB through the I kappaB kinase complex. Epigallocatechin-3-gallate (EGCG) is a polyphenol that induces the expression of CARD 14.

Specifications

• Antigen: CARD14
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CARD14
• Gene Alias: Bcl10-interacting MAGUK protein 2; BIMP2; Card14; CARD-containing MAGUK protein 2; Carma 2; CARMA2; caspase recruitment domain family member 14; caspase recruitment domain family, member 14; caspase recruitment domain-containing protein 14; PRP; PSORS2; PSS1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170720, 688292, 79092
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.12 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q99KF0, Q9BXL6
• Gene Symbols: CARD14
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 200-500 of human CARD14 (NP_001244899.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG