CARD8 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA527695

Catalog No. PIPA527695

Description

Recommended positive controls: 293T, A431, HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pesudo-ICE. Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappa-B activation.

Specifications

• Antigen: CARD8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CARD8
• Gene Alias: Apoptotic protein NDPP1; CARD 8; CARD inhibitor of NF-kappaB-activating ligands; CARD8; CARDINAL; CARD-inhibitor of NF-kappa-B-activating ligand; caspase recruitment domain family member 8; caspase recruitment domain family, member 8; caspase recruitment domain-containing protein 8; DACAR; DAKAR; DKFZp779L0366; KI; KIAA0955; NDPP; NDPP1; TUCAN; Tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22900
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 40% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9Y2G2
• Gene Symbols: CARD8
• Immunogen: Recombinant fragment corresponding to a region within amino acids 215 and 400 of Human CARD8
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG