Cardiac Troponin I Mouse anti-Human, Mouse, Rat, Clone: 1D5D6, Proteintech

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-114-2713	Proteintech Group Inc 663761IG150UL	150 μL

Description

This antibody is specific to cTnI, but not cross-react with skeletal TnI.

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Specifications

• Antigen: Cardiac Troponin I
• Concentration: 1 mg/mL
• Classification: Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: Cardiac troponin I, CMD2A, CMH7, cTnI, RCM1, TNNC1, TNNI3, troponin I type 3 (cardiac), Troponin I, cardiac muscle
• Gene Symbols: TNNI3
• Isotype: IgG1
• Purification Method: Protein G
• Product Type: Antibody

• Clone: 1D5D6
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Mouse
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P19429, P23693, P48787
• Gene ID (Entrez): 21954, 29248, 7137
• Immunogen: Cardiac Troponin I Fusion Protein Ag16758
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: TNNI3