cardiac Troponin I Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-0515	100 μL

Catalog No. 50-198-0515 Supplier Bioss Supplier No. BS0799R

Description

Rabbit Polyclonal Antibody

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Specifications

• Antigen: cardiac Troponin I
• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: TNNI3
• Gene Accession No.: P19429
• Gene Alias: BOS_18114; Cardiac troponin I; cardiac troponin I isoform; cardiomyopathy, dilated 2A (autosomal recessive); CMD1FF; CMD2A; CMH7; Ctni; LOC511094; MGC116817; RCM1; Tn1; Tni; TNNC1; Tnni3; Tpn1; troponin 1, type 3; troponin I type 3 (cardiac); troponin I, cardiac 3; Troponin I, cardiac muscle; troponin I, cardiac muscle-like; troponin I3, cardiac type
• Gene Symbols: TNNI3
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human Cardiac Troponin I.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 7137
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG