Invitrogen™ Cardiac Troponin T Monoclonal Antibody (1F11)

Catalog No.	Quantity
MA124612	200 μg

Catalog No. MA124612 Supplier Invitrogen™ Supplier No. MA124612

Description

Mouse Monoclonal Antibody

MA1-24612 detects a band at approximately 35.4 kDa.

Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results in many tissue-specific isoforms.

Specifications

• Antigen: Cardiac Troponin T
• Applications: Affinity Purification, Western Blot
• Classification: Monoclonal
• Clone: 1F11
• Concentration: 4.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene: TNNT2
• Gene Accession No.: P09741, P13789, P45379, P50752, P50753
• Gene Alias: alternatively spliced; cardiac muscle troponin T; cardiac TnT; cardiac troponin 2; cardiac troponin 2 adult #1 isoform; cardiac troponin 2 adult #2 isoform; cardiac troponin 2 embryonic #1 isoform; cardiac troponin 2 embryonic #2 isoform; cardiac troponin 2, exclusion exon 6 #1 isoform; cardiac troponin 2, exclusion exon 6 #2 isoform; cardiac troponin T; cardiac troponin T form I; cardiac troponin T isoform 1; cardiac troponin T isoform 2; cardiac troponin T isoform I; cardiac troponin T2; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; CMD1D; CMH2; CMPD2; cTnT; Ctt; CTTG; LVNC6; MGC3889; RATCTTG; RCM3; TNNT2; Tnnt3; Tnt; TnTc; troponin T; Troponin T cardiac; troponin T cardiac isoform; troponin T isoform 1; troponin T isoform 2; troponin T splicing mutant isoform 1; troponin T splicing mutant isoform 2; troponin T type 2 (cardiac); troponin T, cardiac muscle; Troponin T, cardiac muscle isoforms; Troponin T2; troponin T2, cardiac; troponin T2, cardiac type; truncated cardiac troponin T
• Gene Symbols: TNNT2
• Host Species: Mouse
• Immunogen: Free human cTnT.
• Purification Method: Protein A
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100009428, 100622450, 102185261, 21956, 24837, 286816, 403532, 493940, 7139
• Target Species: Human, Mouse, Rat, Canine, Rabbit, Bovine, Pig, Feline, Fish, Goat
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b