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Invitrogen™ CARF Polyclonal Antibody
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Catalog No. PIPA556973
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100 μL
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PIPA556973 100 μL
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Catalog No. PIPA556973 Supplier Invitrogen™ Supplier No. PA556973
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SQGIEQVYAV RKQLRKFVER ELFKPDEVPE RHNLSFFPTV NDIKNHIHEV QKSLRNGDTV YNSEIIPATL QWTTDSGNIL KETMTVTFAE GNSPGESITT K Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 88%.

CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CARF
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CARF
Gene Accession No. Q8N187
Gene Alias Als2cr8; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein homolog; calcium response factor; calcium responsive transcription factor; calcium-response factor; calcium-response factor CaRF; calcium-responsive transcription factor; CaRF; ECBRC-FC1; ECBRC-FC2; NYD-SP24; testis development protein NYD-SP24
Gene Symbols CARF
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CARF. Recombinant protein control fragment (Product #RP-96099).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79800
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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