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Invitrogen™ Caronte Polyclonal Antibody
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Catalog No. PIPA547055
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100 μg
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PIPA547055 100 μg
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Catalog No. PIPA547055 Supplier Invitrogen™ Supplier No. PA547055
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Description

Goat Polyclonal Antibody

In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) Cerberus-1 is observed and less than 1% cross-reactivity with rhDAN and recombinant mouse Gremlin is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Chicken Caronte, the ortholog of mammalian Cerberus, is a member of the Cerberus/DAN family of secreted glycoproteins. There are at least 5 Dan Domain (DAND) family members including DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus; DAND3), Cerberus (DAND4), and Coco (DAND5). Caronte is expressed in the left paraxial mesoderm and is the molecule responsible for transducing left-sided positional information from the node to the periphery of the lateral plate mesoderm (LPM) during chicken embryonic development. Caronte functions as a BMP antagonist, inducing Nodal and downstream genes in the LPM by interfering with the repressive activity of bilaterally-produced BMPs. In addition, antagonism of BMPs by Caronte induces the expression of the Lefty gene in the midline.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caronte
Applications Neutralization, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Alias CER1; Cerberus; cerberus 1, cysteine knot superfamily, homolog; cerberus 1, DAN family BMP antagonist; cerberus-related 1; cerberus-related protein; Chicken Caronte; DAN domain family member 4; DAND4
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant chicken Caronte Asp16-Asn272.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chicken
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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