Invitrogen™ CAS Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597222

Catalog No. PIPA597222

Description

Immunogen sequence: LEKSQDNVIK VCASVTFKNY IKRNWRIVED EPNKICEADR VAIKANIVHL MLSSPEQIQK QLSDAISIIG REDFPQKWPD LLTEMVNRFQ SGDFHVINGV L; Positive Samples: B cells, U-87MG, LO2, BT-474; Cellular Location: Cytoplasm, Nucleus.

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.

Specifications

• Antigen: CAS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CSE1L
• Gene Alias: 2610100P18Rik; AA407533; Capts; CAS; Cellular apoptosis susceptibility protein; chromosome segregation 1 like; chromosome segregation 1-like (S. cerevisiae); chromosome segregation 1-like protein; CSE1; CSE1 chromosome segregation 1 like; CSE1 chromosome segregation 1-like; CSE1 chromosome segregation 1-like (yeast); CSE1L; Exp2; exportin-2; Importin-alpha re-exporter; MGC117283; MGC130036; MGC130037; XPO2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1434, 362273
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 4.32 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P55060
• Gene Symbols: CSE1L
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Exportin 2 (XPO2) (NP_0012430641).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG