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Invitrogen™ Casc5 Polyclonal Antibody
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Catalog No. PIPA555360
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100 μL
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PIPA555360 100 μL
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Catalog No. PIPA555360 Supplier Invitrogen™ Supplier No. PA555360
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HHTEEDIDKS ANSVLIKNLS RTPSSCSSSL DSIKADGTSL DFSTYRSSQM ESQFLRDTIC EESLREKLQD GRITIREFFI LLQVHILIQK PRQSNLPGNF TVNTPPTPED LMLSQYVYRP KIQIYREDCE ARRQKIEELK LSASNQDKL Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 81%.

Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Casc5
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene KNL1
Gene Accession No. Q8NG31
Gene Alias 2310043D08Rik; 5730505K17Rik; AF15Q14; ALL1-fused gene from chromosome 15q14 protein; Blinkin; blinkin, bub-linking kinetochore protein; Bub-linking kinetochore protein; cancer susceptibility candidate 5; cancer susceptibility candidate gene 5 protein; Cancer/testis antigen 29; CASC5; CT29; D40; hKNL-1; hSpc105; KIAA1570; kinetochore null 1 homolog; kinetochore scaffold 1; Kinetochore-null protein 1; KNL1; MCPH4; microcephaly, primary autosomal recessive 4; PPP1R55; Protein CASC5; Protein D40/AF15q14; protein phosphatase 1, regulatory subunit 55; Rad51; RAD51 homolog; Spc7
Gene Symbols KNL1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human Casc5. Recombinant protein control fragment (Product #RP-92565).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57082
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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