CASP1 Mouse anti-Human, Clone: 14F468, Abnova™

Catalog No.	Quantity
89-933-722	50 μg

Catalog No. 89-933-722 Supplier Abnova Corporation Supplier No. MAB12509

Description

Mouse monoclonal antibody raised against human CASP1.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq]

Sequence: RKVRFSFEQPDGRAQMPTTE

Specifications

• Antigen: CASP1
• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Classification: Monoclonal
• Clone: 14F468
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against human CASP1.
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL) Western Blot (0.5-2 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.05% BSA, 0.05% sodium azide).
• Gene Alias: ICE/IL1BC/P45
• Gene Symbols: CASP1
• Host Species: Mouse
• Immunogen: A synthetic peptide corresponding to amino acids 371-390 of human CASP1.
• Purification Method: Protein G purification
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 834
• Target Species: Human
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid
• Isotype: IgG1 κ