CASP3 Mouse anti-Human, Mouse, Rat, Clone:3D4D10, Abnova™

Mouse monoclonal antibody raised against recombinant human CASP3.

Supplier:  Abnova Corporation MAB16670

Catalog No. 89-333-120

Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer′s disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq]

Specifications

• Antigen: CASP3
• Classification: Monoclonal
• Conjugate: Unconjugated
• Dilution: ELISA (1:10000)
  Western Blot (1:500-1:2000)
  Immunohistochemistry
  Immunocytochemistry
  Flow Cytometry
  The optimal working dilution should be determined by the end user.
• Gene: CASP3
• Host Species: Mouse
• Quantity: 100 μg
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: 3D4D10
• Description: caspase 3, apoptosis-related cysteine peptidase
• Formulation: In PBS (0.05% sodium azide)
• Gene Alias: CPP32, CPP32B, SCA-1
• Immunogen: Recombinant protein corresponding to amino acid 29-175 of human CASP3 from E. coli.
• Gene ID (Entrez): 836
• Content And Storage: Store at 4°C. For long term storage store at -20°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid