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Invitrogen™ Caspase 1 (cleaved Asp297) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA577886

Catalog No. PIPA577886


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Description

Description

Positive Control: conditioned medium of treated THP-1, THP-1 conditioned medium (500 ng/mL LPS treatment for 4 hr in serum free and 1 mM ATP treatment for 1.5 hr) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Caspase 1 (cleaved Asp297) encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase 1 (cleaved Asp297) was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. Caspase 1 (cleaved Asp297) has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Caspase 1 (cleaved Asp297)
Polyclonal
Unconjugated
CASP1
CASP1; CASP-1; CASP1 nirs variant 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; ICE; IL-1 beta-converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
Rabbit
Antigen affinity chromatography
RUO
834
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
1 mg/mL
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
P29466
CASP1
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of Human Caspase 1 (cleaved Asp297). The exact sequence is proprietary.
100 μL
Primary
Human
Antibody
IgG
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