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Invitrogen™ Caspase 1 (cleaved Asp297) Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA577886
Description
Positive Control: conditioned medium of treated THP-1, THP-1 conditioned medium (500 ng/mL LPS treatment for 4 hr in serum free and 1 mM ATP treatment for 1.5 hr) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Caspase 1 (cleaved Asp297) encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase 1 (cleaved Asp297) was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. Caspase 1 (cleaved Asp297) has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Specifications
Caspase 1 (cleaved Asp297) | |
Polyclonal | |
Unconjugated | |
CASP1 | |
CASP1; CASP-1; CASP1 nirs variant 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; ICE; IL-1 beta-converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
834 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
1 mg/mL | |
PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
P29466 | |
CASP1 | |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of Human Caspase 1 (cleaved Asp297). The exact sequence is proprietary. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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