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Invitrogen™ CASPASE 1 P10 (CLEAVED ALA317) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105049

Catalog No. PIPA5105049


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Description

Description

Antibody detects endogenous levels of fragment of activated Caspase-1 resulting from cleavage adjacent to Ala317.

Caspase-1 (CASP1) is a thiol protease that cleaves IL-1 beta between Asp and Ala. This cleavage causes the release of the mature cytokine which is involved in a variety of inflammatory processes. CASP1 is important for defense against pathogen. It cleaves and activates sterol regulatory element binding proteins (SREBPs). CASP1 also promotes apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, CASP1 controls antiviral immunity through the cleavage of CGAS and renders it inactive.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CASPASE 1 P10 (CLEAVED ALA317)
Polyclonal
Unconjugated
CASP1
Casp1; CASP-1; CASP1 nirs variant 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45
Rabbit
Affinity Chromatography
RUO
12362, 25166, 834
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P29452, P29466, P43527
CASP1
A synthesized peptide derived from human CASP1(Accession P29466), corresponding to amino acid residues T310-S332.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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