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Invitrogen™ Caspase 1 p20 (Cleaved Asp296) Polyclonal Antibody
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Catalog No. PIPA599390
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100 μL
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PIPA599390 100 μL
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Catalog No. PIPA599390 Supplier Invitrogen™ Supplier No. PA599390
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of fragment of activated Caspase-1 resulting from cleavage adjacent to Asp296.

Caspase-1 p20 (cleaved Asp296) refers to the large catalytic subunit generated during activation of pro-caspase-1, an inflammatory cysteine protease encoded by the CASP1 gene. Caspase-1 is synthesized as an inactive zymogen and becomes activated within multiprotein inflammasome complexes in response to infection, cellular stress, or danger-associated signals. Activation involves autoproteolytic cleavage at specific aspartic acid residues, including at Asp296, producing the p20 (large) and p10 (small) subunits that assemble into the active heterotetrameric enzyme. The p20 fragment contains part of the catalytic domain and is commonly used as a marker of caspase-1 activation. Active caspase-1 mediates the proteolytic maturation of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and interleukin-18 (IL-18) and drives pyroptosis, an inflammatory form of programmed cell death. Detection of cleaved caspase-1 p20 (Asp296) is therefore widely used to assess inflammasome activation in immunology and inflammation research.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 1 p20 (Cleaved Asp296)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene CASP1
Gene Accession No. P29452, P29466, P43527
Gene Alias CASP1; Caspase-1 (Asp296 cleaved); Caspase-1 (cleaved Asp296); Cleaved Caspase-1 p20
Gene Symbols CASP1
Host Species Rabbit
Immunogen A synthesized peptide derived from human CASP1(Accession P29466), corresponding to amino acid residues I280-V299.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12362, 25166, 834
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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