Invitrogen™ Caspase 10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120032

Catalog No. PIPA5120032

Description

Positive test controls include: Jurkat, NIH/3T3. Immunogen sequence: VKTFLEALPQ ESWQNKHAGS NGNRATNGAP SLVSRGMQGA SANTLNSETS TKRAAVYRMN RNHRGLCVIV NNHSFTSLKD RQGTHKDAEI LSHVFQWLGF TVHIHNNVTK VEMEMVLQKQ KCNPAHADGD CFVFCILTHG RFGAVYSSDE ALIPIREIMS HFTALQCPRL AEKPKLFFIQ ACQGEEIQPS VSIEADALNP EQAPTSLQDS IPAEADFLLG LATVPGYVSF RHVEEGSWYI QSLCNHLKKL VPRHEDILSI LTAVNDDVSR RVDKQGTKKQ MPQPAFTLRK KLVFPVPLDA LS.

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Specifications

• Antigen: Caspase 10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CASP10
• Gene Alias: ALPS2; Apoptotic protease Mch-4; CASP10; CASP-10; caspase 10; caspase 10 apoptosis-related cysteine peptidase; caspase 10, apoptosis-related cysteine peptidase; caspase 10, apoptosis-related cysteine protease; caspase-10; Caspase-10 subunit p12; Caspase-10 subunit p23/17; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; MCH4
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 843
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.38 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q92851
• Gene Symbols: CASP10
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 220-521 of human Caspase-10 (NP_1167592).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG