Invitrogen™ Caspase 12 Monoclonal Antibody (14F7)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA124704

Catalog No. PIMA124704

Description

Recommended positive controls: NRK.

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Specifications

• Antigen: Caspase 12
• Classification: Monoclonal
• Concentration: 2.2 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: O08736, Q920D5
• Gene Symbols: CASP12
• Immunogen: Recombinant fragment corresponding to residues 95-318 of mouse Caspase 12.
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 14F7
• Conjugate: Unconjugated
• Gene: CASP12
• Gene Alias: CASP12; CASP-12; CASP12P1; caspase 12; caspase 12 (gene/pseudogene); caspase 12 pseudogene 1; caspase-12; Inactive caspase-12; OTTMUSP00000045799; OTTMUSP00000045802; OTTMUSP00000045803; UNQ9415; UNQ9415/PRO34398
• Host Species: Rat
• Purification Method: Purified
• Regulatory Status: RUO
• Gene ID (Entrez): 12364, 156117
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid