Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA519963

Invitrogen™ Caspase 12 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA519963
Change view
Click to view available options
Quantity:
100 μg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA519963 100 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA519963 Supplier Invitrogen™ Supplier No. PA519963
Only null left
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse brain tissue lysate. PA5-19963 can be used with blocking peptide PEP-0088.

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 12
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CASP12
Gene Accession No. O08736, Q6UXS9, Q920D5
Gene Alias CASP12; CASP-12; CASP12P1; caspase 12; caspase 12 (gene/pseudogene); caspase 12 pseudogene 1; caspase-12; Inactive caspase-12; OTTMUSP00000045799; OTTMUSP00000045802; OTTMUSP00000045803; UNQ9415; UNQ9415/PRO34398
Gene Symbols CASP12
Host Species Rabbit
Immunogen A peptide corresponding to amino acids 90 to 140 of murine caspase-12.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100506742, 12364, 156117
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.