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Invitrogen™ Caspase 12 Polyclonal Antibody
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Catalog No. PIPA587375
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100 μL
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PIPA587375 100 μL
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Catalog No. PIPA587375 Supplier Invitrogen™ Supplier No. PA587375
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FNNRNCQSLK DKPKVIIMQA CRGNGAGIVW FTTDSGKASA DTHGRLLQGN ICNDAVTKAH VEKDFIAFKS STPHNVSWRH ETNGSVFISQ IIYYFREYSW S Positive Samples: Jurkat, Mouse lung, Mouse ovary, Mouse uterus, Rat lung.

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 12
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.368 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CASP12
Gene Accession No. O08736, Q6UXS9, Q920D5
Gene Alias CASP12; CASP-12; CASP12P1; caspase 12; caspase 12 (gene/pseudogene); caspase 12 pseudogene 1; caspase-12; Inactive caspase-12; OTTMUSP00000045799; OTTMUSP00000045802; OTTMUSP00000045803; UNQ9415; UNQ9415/PRO34398
Gene Symbols CASP12
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-12 (NP_0011779452).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100506742, 12364, 156117
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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