Invitrogen™ Caspase 12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587375

Catalog No. PIPA587375

Description

Immunogen sequence: FNNRNCQSLK DKPKVIIMQA CRGNGAGIVW FTTDSGKASA DTHGRLLQGN ICNDAVTKAH VEKDFIAFKS STPHNVSWRH ETNGSVFISQ IIYYFREYSW S Positive Samples: Jurkat, Mouse lung, Mouse ovary, Mouse uterus, Rat lung.

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Specifications

• Antigen: Caspase 12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CASP12
• Gene Alias: CASP12; CASP-12; CASP12P1; caspase 12; caspase 12 (gene/pseudogene); caspase 12 pseudogene 1; caspase-12; Inactive caspase-12; OTTMUSP00000045799; OTTMUSP00000045802; OTTMUSP00000045803; UNQ9415; UNQ9415/PRO34398
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100506742, 12364, 156117
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.368 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O08736, Q6UXS9, Q920D5
• Gene Symbols: CASP12
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Caspase-12 (NP_0011779452).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG