Caspase 12 Polyclonal Antibody, Rockland™

Rabbit Polyclonal Antibody

Supplier:  Rockland Immunochemicals 600401MJ3S

Catalog No. 50-199-2313

Description

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This affinity purified antibody is directed against mouse Caspase 12. A BLAST analysis was used to suggest reactivity with the antigen based on 100% homology with the immunizing sequence.

Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Specifications

• Antigen: Caspase 12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CASP12
• Gene Alias: CASP12; CASP-12; CASP12P1; caspase 12; caspase 12 (gene/pseudogene); caspase 12 pseudogene 1; Caspase-12; Inactive caspase-12; OTTMUSP00000045799; OTTMUSP00000045802; OTTMUSP00000045803; UNQ9415; UNQ9415/PRO34398
• Host Species: Rabbit
• Regulatory Status: RUO
• Gene ID (Entrez): 12364, 156117
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunofluorescence, Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene Accession No.: O08736, Q920D5
• Gene Symbols: CASP12
• Quantity: 25 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody