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Caspase 12 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody
$518.60
Specifications
Antigen | Caspase 12 |
---|---|
Concentration | 0.4 mg/mL |
Applications | Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot |
Classification | Polyclonal |
Conjugate | Unconjugated |
Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
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Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-173-6074
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Proteintech Group Inc
552381AP150UL |
150 μL |
Each of 1 for $518.60
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Description
This antibody does not cross-react with other caspases.
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer′s disease including -gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.Specifications
Caspase 12 | |
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
Unconjugated | |
Rabbit | |
Human | |
Q6UXS9 | |
100506742 | |
Peptide | |
Primary | |
-20°C | |
CASP12 |
0.4 mg/mL | |
Polyclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
CASP 12, CASP12, CASP12P1, caspase 12 (gene/pseudogene), Caspase12, Inactive caspase 12 | |
CASP12 | |
IgG | |
Antigen Affinity Chromatography | |
Antibody |
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