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Invitrogen™ Caspase 14 Polyclonal Antibody
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Catalog No. PIPA580408
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100 μL
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PIPA580408 100 μL
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Catalog No. PIPA580408 Supplier Invitrogen™ Supplier No. PA580408
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Description

Rabbit Polyclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human Caspase-14/CASP14.

Caspase 14 encodes a member of the cysteine-aspartic acid protease (caspase) family, which plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. Diseases associated with CASP14 include Ichthyosis, Congenital, Autosomal Recessive 12 and Autosomal Recessive Congenital Ichthyosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 14
Applications ELISA, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Casp14
Gene Accession No. P31944
Gene Alias apoptosis-related cysteine protease; CASP14; CASP-14; caspase 14; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis-related cysteine protease; Caspase14; caspase-14; Caspase-14 subunit p10, mature form; Caspase-14 subunit p17, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form; caspase-14; LOW QUALITY PROTEIN: caspase-14; MICE; Mini-ICE
Gene Symbols Casp14
Host Species Rabbit
Immunogen Recombinant Human Caspase-14/CASP14 protein (Ser2-Gln242).
Purification Method Antigen affinity chromatography, Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23581
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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