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Invitrogen™ Caspase 14 Recombinant Rabbit Monoclonal Antibody (6E2C1)
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Catalog No. PIMA538191
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PIMA538191 100 μL
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Catalog No. PIMA538191 Supplier Invitrogen™ Supplier No. MA538191
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: SH-SY5Y, Mouse thymus, A375, Mouse stomach, Rat lung, Rat stomach Immunogen sequence: GEMVKLENLF EALNNKNCQA LRAKPKVYII QACRGEQRDP GETVGGDEIV MVIKDSPQTI PTYTDALHVY STVEGYIAYR HDQKGSCFIQ TLVDVFTKRK G.

Caspase 14 encodes a member of the cysteine-aspartic acid protease (caspase) family, which plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. Diseases associated with CASP14 include Ichthyosis, Congenital, Autosomal Recessive 12 and Autosomal Recessive Congenital Ichthyosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 14
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 6E2C1
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Casp14
Gene Accession No. O89094, P31944
Gene Alias apoptosis-related cysteine protease; CASP14; CASP-14; caspase 14; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis-related cysteine protease; Caspase14; caspase-14; Caspase-14 subunit p10, mature form; Caspase-14 subunit p17, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form; caspase-14; LOW QUALITY PROTEIN: caspase-14; MICE; Mini-ICE
Gene Symbols Casp14
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 100-200 of human Caspase-14 (P31944).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12365, 23581, 299587
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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