Caspase-3 Mouse anti-Human, Mouse, Rat, Clone: 31A1067, Active Motif™

Catalog No.	Quantity
50-199-3046	100 μg

Catalog No. 50-199-3046 Supplier Active Motif Supplier No. 40924

Description

Mouse Monoclonal Antibody

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Specifications

• Antigen: Caspase-3
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 31A1067
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide; pH 7.5
• Gene: CASP3
• Gene Accession No.: P42574, P55213, P70677
• Gene Alias: A830040C14Rik; AC-3; Apopain; Apopain precursor; CASP3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase3; Caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; Caspase-3-like protein; CC3; CPP32; CPP-32; CPP32B; CPP32beta; Cysteine protease CPP32; ICE3; IRP; LICE; mldy; PARP cleavage protease; procaspase3; Protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
• Gene Symbols: CASP3
• Host Species: Mouse
• Immunogen: This Caspase-3 antibody was raised against a 6xHis-Tag full-length human Caspase-3 protein.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12367, 25402, 836
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1