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Invitrogen™ Caspase 3 p17 Polyclonal Antibody
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Catalog No. PIPA578921
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100 μg
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Catalog No. Quantity
PIPA578921 100 μg
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Catalog No. PIPA578921 Supplier Invitrogen™ Supplier No. PA578921
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Rat Heart Tissue, Rat Liver Tissue, Rat Thymus Tissue, Rat Spleen Tissue, mouse thymus tissue, mouse spleen tissue, mouse lung tissue, mouse brain tissue, mouse testis tissue. IHC: rat intestine tissue.

CASP3 (Caspase3 Apoptosis-Related Cysteine Protease), also known as YAMA, CPP32 or APOPAIN, is a caspase protein that interacts with caspase 8 and caspase 9. It is encoded by the CASP3 gene. The CASP3 protein is a member of the cysteine-aspartic acid protease (caspase) family. Tiso et al. (1996) used radiation hybrid mapping to localize the CPP32 gene to human chromosome 4q33-q35.1. Fernandes-Alnemri et al. (1994) found that overexpression of CPP32 in insect cells induced apoptosis. Coexpression of the 2 CPP32 subunits in insect cells also resulted in apoptosis. Tewari et al. (1995) showed that purified human ICE cleaved the Yama proenzyme into a proteolytically active form and that activated Yama cleaved PARP into the 85-kD apoptotic form.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 3 p17
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
Gene CASP3
Gene Accession No. P55213, P70677
Gene Alias A830040C14Rik; AC-3; Apopain; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; CC3; Cleaved Caspase 3; Cpp32; CPP-32; CPP32beta; cysteine protease CPP32; IRP; LICE; mldy; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
Gene Symbols CASP3
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of mouse Caspase-3 (P17) (67-81aa TDVDAANLRETFMGL).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12367, 25402
Target Species Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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