Invitrogen™ Caspase 4/5 p20 (Cleaved Asp270, Asp311) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA539873

Catalog No. PIPA539873

Description

Caspase 4/5 p20 (Cleaved Asp270, Asp311) Polyclonal Antibody for Western Blot

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Specifications

• Antigen: Caspase 4/5 p20 (Cleaved Asp270, Asp311)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CASP4
• Gene Alias: apoptotic cysteine protease Mih1/TX; CASP4; CASP-4; CASP5; CASP-5; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; caspase 5; caspase 5, apoptosis-related cysteine peptidase; caspase 5, apoptosis-related cysteine protease; caspase-4; Caspase-4 subunit 1; Caspase-4 subunit 2; Caspase-5; Caspase-5 subunit p10; Caspase-5 subunit p20; ICE and Ced-3 homolog 2; ICE(rel)II; ICE(rel)-II; ICE(rel)III; ICE(rel)-III; ICEREL-II; ICEREL-III; ICH2; ICH-2; ICH3; ICH-3; Mih1; Mih1/TX; protease ICH-2; protease ICH-3; protease protease ICE(rel)III; protease protease TY; Protease TX; protease TY; TX; TY protease
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 837, 838
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: Dulbecco's PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P49662, P51878
• Gene Symbols: CASP4, CASP5
• Immunogen: A synthetic peptide derived from human Caspase 4/5.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov