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Invitrogen™ Caspase 4 Polyclonal Antibody
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Catalog No. PIPA529788
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100 μL
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PIPA529788 100 μL
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Catalog No. PIPA529788 Supplier Invitrogen™ Supplier No. PA529788
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: H1299, K562, THP-1, HL-60, myc-tagged human caspas4-transfected 293T cells. Predicted reactivity: Rhesus Monkey (96%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 4
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.89 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene CASP4
Gene Accession No. P49662
Gene Alias apoptotic cysteine protease Mih1/TX; Casp11; CASP-11; CASP4; CASP-4; caspase 11; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-11; Caspase-4; Caspase-4 subunit 1; Caspase-4 subunit 2; Caspase-4 subunit p10; Caspase-4 subunit p20; Caspl; ICE and Ced-3 homolog 2; ICE(rel)II; ICE(rel)-II; ICEREL-II; ICH2; ICH-2; Ich3; ich-3; Mih1; Mih1/TX; protease ICH-2; Protease ICH-3; Protease TX; TX
Gene Symbols CASP4
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Caspase 4. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 837
Target Species Human, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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