Invitrogen™ Caspase 4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120670

Catalog No. PIPA5120670

Description

Positive test controls include: SW620. Immunogen sequence: QISPNKKAHP NMEAGPPESG ESTDALKLCP HEEFLRLCKE RAEEIYPIKE RNNRTRLALI ICNTEFDHLP PRNGADFDIT GMKELLEGLD YSVDVEENLT ARDMESALRA FATRPEHKSS DSTFLVLMSH GILEGICGTV HDEKKPDVLL YDTIFQIFNN RNCLSLKDKP KVIIVQACRG ANRGELWVRD.

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Specifications

• Antigen: Caspase 4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CASP4
• Gene Alias: apoptotic cysteine protease Mih1/TX; Casp11; CASP-11; CASP4; CASP-4; caspase 11; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-11; Caspase-4; Caspase-4 subunit 1; Caspase-4 subunit 2; Caspase-4 subunit p10; Caspase-4 subunit p20; Caspl; ICE and Ced-3 homolog 2; ICE(rel)II; ICE(rel)-II; ICEREL-II; ICH2; ICH-2; Ich3; ich-3; Mih1; Mih1/TX; protease ICH-2; Protease ICH-3; Protease TX; TX
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 837
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.776 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P49662
• Gene Symbols: CASP4
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 81-270 of human Caspase-4 (NP_0012161).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG