Invitrogen™ Caspase 5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5102876

Catalog No. PIPA5102876

Description

Antibody detects endogenous levels of total Caspase 5.

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1-b and IL-18. Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1-b. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma.

Specifications

• Antigen: Caspase 5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CASP5
• Gene Alias: CASP5; CASP-5; caspase 5; caspase 5, apoptosis-related cysteine peptidase; caspase 5, apoptosis-related cysteine protease; caspase-5; Caspase-5 subunit p10; Caspase-5 subunit p20; ICE(rel)III; ICE(rel)-III; ICEREL-III; ICH3; ICH-3; Protease ICH-3; protease TY; TY protease
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 838
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P51878
• Gene Symbols: CASP5
• Immunogen: A synthesized peptide derived from human CASP5(Accession P51878), corresponding to amino acid residues S118-R168.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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