Invitrogen™ Caspase 6 Monoclonal Antibody (M378)

Catalog No.	Quantity
PIMA547700	100 μL

Catalog No. PIMA547700 Supplier Invitrogen™ Supplier No. MA547700

Description

Mouse Monoclonal Antibody

The antibody detects a 34 kDa* protein corresponding to the molecular weight of Caspase-6 on SDS-PAGE immunoblots of human Jurkat, K562, and A431 cells.

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.

Specifications

• Antigen: Caspase 6
• Applications: Western Blot
• Classification: Monoclonal
• Clone: M378
• Concentration: 0.25 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
• Gene: Casp6
• Gene Accession No.: P55212
• Gene Alias: apoptotic protease MCH-2; CASP6; CASP-6; caspase 6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; caspase-6; Caspase-6 subunit p11; Caspase-6 subunit p18; mCASP-6; MCH2
• Gene Symbols: Casp6
• Host Species: Mouse
• Immunogen: Clone (M378) was generated from a peptide containing amino acid residues in the C-terminal region of human Caspase-6.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 839
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1