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Invitrogen™ Caspase 6 (Cleaved Asp179) Polyclonal Antibody
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Catalog No. PIPA599464
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100 μL
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PIPA599464 100 μL
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Catalog No. PIPA599464 Supplier Invitrogen™ Supplier No. PA599464
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of fragment of activated Caspase 6 resulting from cleavage adjacent to Asp179.

Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Caspase 6 (Cleaved Asp179)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Casp6
Gene Accession No. O35397, P55212
Gene Alias apoptotic protease MCH-2; CASP6; CASP-6; caspase 6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; caspase-6; Caspase-6 subunit p11; Caspase-6 subunit p18; mCASP-6; MCH2
Gene Symbols Casp6
Host Species Rabbit
Immunogen A synthesized peptide derived from human CASP6(Accession P55212), corresponding to amino acid residues C163-I189.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 83584, 839
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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