Invitrogen™ Caspase 7 (Cleaved Asp198) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114688

Catalog No. PIPA5114688

Description

Antibody detects endogenous levels of fragment of activated Caspase 7 resulting from cleavage adjacent to Asp198.

Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.

Specifications

• Antigen: Caspase 7 (Cleaved Asp198)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CASP7
• Gene Alias: AI314680; Apoptotic protease Mch-3; Casp7; CASP-7; caspase 7; caspase 7 isoform delta; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; caspase-7; Caspase-7 subunit p11; Caspase-7 subunit p20; CMH-1; Cysteine protease LICE2; ICE-IAP3; ICE-LAP3; ICE-like apoptotic protease 3; Lice2; Lice2 alpha/beta/gamma; mCASP-7; MCH3; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12369, 840
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P55210, P97864
• Gene Symbols: CASP7
• Immunogen: A synthesized peptide derived from human CASP7(Accession P55210), corresponding to amino acid residues P178-A207.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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