Invitrogen™ Caspase 7 Monoclonal Antibody (S.606.3)

Catalog No.	Quantity
PIMA515159	100 μL

Catalog No. PIMA515159 Supplier Invitrogen™ Supplier No. MA515159

Description

Mouse Monoclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other caspases.

Caspase 7 is part of a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase 7 is an executioner caspase that was identified based on its homology with caspases 1 and 3, as well as the C. elegans cell death protein CED-3. Alternative splicing of Caspase-7 mRNA results in the production of 3 distinct isoforms. Caspase-7 activity can be directly inhibited by XIAP expression. Alternative splicing results in four transcript variants, encoding three distinct isoforms of Caspase 7. Diseases associated with CASP7 include Type 1 Diabetes Mellitus 17 and Aleutian Mink Disease.

Specifications

• Antigen: Caspase 7
• Applications: Western Blot
• Classification: Monoclonal
• Clone: S.606.3
• Concentration: 140 μg/mL
• Conjugate: Unconjugated
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
• Gene: CASP7
• Gene Accession No.: P55210
• Gene Alias: AI314680; Apoptotic protease Mch-3; Casp7; CASP-7; caspase 7; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; caspase-7; Caspase-7 subunit p11; Caspase-7 subunit p20; CMH-1; cysteine protease LICE2; ICE-IAP3; ICE-LAP3; ICE-like apoptotic protease 3; Lice2; mCASP-7; MCH3; OTTHUMP00000020511; OTTHUMP00000020513; OTTHUMP00000020514; RP11-211N11.6
• Gene Symbols: CASP7
• Host Species: Mouse
• Immunogen: Recombinant human caspase-7 protein.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 840
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov